curative and prophylactic propertics of sotalol and propranolol on adrenaline induced arrhysthmia

Sotalol is a non selective beta adrenoceptor blocking agent that differs from propranolol in having no membrane stabilising properties. In the present study the antiarrysthmic, effect of sotalol was shown when injected immediately after, or 2 minutes before adrenaline injection in anaesthetised dogs. 2mg/ Kg b.w. sotalol prevented as well as cured arrhythmic effect of even large dose of adrenaline while 0.2mg/ Kg b.w. propranolol was needed to produce the same effect. Sotalol was also evaluated clinically as regards its usefulness against the cardiac arrhythmia that may arise in patients after infiltration of adrenaline in the presence of halothane anaesthesia

Comparative study of the analeptic-respirogenic agents doxapram HCl and nikethamide: I - the acute toxicity and analeptic activity in mice

LD50 determinations showed that both Doxapram HCl and Nikethamide fall in the category of moderate toxicity; but Doxapram HCl was the less toxic. Assessment of the arousal capacity of Doxapram HCl against sleeping doses of pentobarbitone sodium in mice demonstrated that the drug has a high therapeutic index. Assessment of the restorative activity of Doxapram HCl and of Nikethamide against toxic doses of pentobarbitone sodium as percentage survival in mice, demonstrated the higher potency of Doxapram HCl

Comparative study of the analeptic-respirogenic agents doxapram HCl and nikethamide: II - respirogenic and cardiovascular pharmacodynamic activites in dogs

Experiments in pentobarbitone-sodium anesthetized dogs revealed that Doxapram HCl was a more potent respirogenic agent than Nikethamide; but at higher doses tachyphylaxis develops. Further assessments of its respirogenic activity in halothane-anesthetized dogs, by calculation of the minutevolume demonstrated a significant increase in ventilatic. These respirogenic effects were accompanied by transientrise in blood pressure at lower doses, and by bradycardia at higher doses. Nikethamide lowered the blood pressure at all dose levels, while it produced no ECG changes. Both drugs produced a dose-related direct myocardial depression of the isolated heart. The site of the respirogenic and cardiovascular effects of Doxapram HCl, was investigated after vagotomy, by intravertebral injection and in the spinal dog. The results demonstrated that the drug acts by central and peripheral mechnisms; and that its action may be partly through sympathetic influence